Project Description: 

Achalasia is a rare neurodegenerative esophageal disorder that presents with two key complications – dysmotility of the esophagus which describes the loss of peristalsis, the wave-like contractions through the esophagus that assist in swallowing, and a constricted lower esophageal sphincter (LES) preventing food from entering the stomach. Patients often struggle to swallow food or large amounts of liquid causing frequent regurgitations due to bolus being stuck in the esophagus. Current treatments address the constricted LES to relieve achalasia symptoms, however, these treatments are not permanent and often accompanied by complications such as acid reflux. There are currently no treatments that address the other main complication, esophageal dysmotility. Our device, the Esophageal Contractile Ring (EsCR), sits around the outside of the esophagus and senses when a bolus approaches the ring. Once that bolus has passed the ring, the ring contracts, creating pressure above the bolus and pushing it down the esophagus. Multiple EsCRs can be implanted along the esophagus to mechanically mimic peristalsis. A full restoration of peristalsis for achalasia patients would allow them to return to a normal diet and regain a positive relationship with food, while also minimizing the complications and symptoms that arise from achalasia and other achalasia treatments.